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GW280264X

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产品信息

产品名称：GW280264X	纯度：98% min
CAS NO：866924-39-2	溶解度：
分子式：C₂₈H₄₁N₅O₆S	包装：可按客户要求包装
分子量：575.72	贮存：-20℃

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备注说明

GW280264X is an ADAM17 inhibitor.

参考文献

1: Yang J, LeBlanc ME, Cano I, Saez-Torres KL, Saint-Geniez M, Ng YS, D'Amore PA. ADAM10 and ADAM17 proteases mediate proinflammatory cytokine-induced and constitutive cleavage of endomucin from the endothelial surface. J Biol Chem. 2020 May 8;295(19):6641-6651. doi: 10.1074/jbc.RA119.011192. Epub 2020 Mar 19. PMID: 32193206; PMCID: PMC7212652.

2: Kouam PN, Rezniczek GA, Adamietz IA, Bühler H. Ionizing radiation increases the endothelial permeability and the transendothelial migration of tumor cells through ADAM10-activation and subsequent degradation of VE-cadherin. BMC Cancer. 2019 Oct 16;19(1):958. doi: 10.1186/s12885-019-6219-7. PMID: 31619190; PMCID: PMC6794838.