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MK-2048

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产品信息

产品名称：MK-2048	纯度：99% min
CAS NO：870005-19-9	溶解度：10 mM in DMSO
分子式：C₂₁H₂₁ClFN₅O₄	包装：可按客户要求包装。
分子量：461.874	贮存：-20℃

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备注说明

MK-2048 is a a second-generation HIV-1 integrase inhibitor. MK-2048 represents a prototype second-generation integrase strand transfer inhibitor (INSTI) developed with the goal of retaining activity against viruses containing mutations associated with resistance to first-generation INSTIs, raltegravir (RAL) and elvitegravir (EVG).

参考文献

[1]. L. Van Wesenbeeck, E. Rondelez, M. Feyaerts, et al. Cross-Resistance Profile Determination of Two Second-Generation HIV-1 Integrase Inhibitors Using a Panel of Recombinant Viruses Derived from Raltegravir-Treated Clinical Isolates .Antimicrob. Agents Chem

[2]. Muhammad Esa Seegulam, Lee Ratner. Integrase Inhibitors Effective against Human T-Cell Leukemia Virus Type 1. Antimicrob. Agents Chemother. 2011, 55 (5): 2011-2017