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产品描述:
S1RA是一种选择性sigma-1 receptor (σ1R)拮抗剂,对人源σ1受体的结合亲和力Ki为17 nM。
英文别名:
DA-42566; HY-18099; MCULE-6623106441; CS-2187; KB-310870
[1]. Díaz JL, et al. Synthesis and biological evaluation of the 1-arylpyrazole class of σ(1) receptor antagonists: identification of 4-{2-[5-methyl-1-(naphthalen-2-yl)-1H-pyrazol-3-yloxy]ethyl}morpholine (S1RA, E-52862). J Med Chem. 2012 Oct 11;55(19):8211-24.
[2]. Romero L, et al. Pharmacological properties of S1RA, a new sigma-1 receptor antagonist that inhibits neuropathic pain and activity-induced spinal sensitization. Br J Pharmacol. 2012 Aug;166(8):2289-306.
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