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巴佛洛霉素A1,Bafilomycin A1一种从链霉菌属物种中分离的大环内酯类抗生素,是特异的 vacuolar-type H+ ATPase (V-ATPase) 抑制剂。Bafilomycin A1 抑制自噬。
物化属性:
密度:1.12
沸点:770.1 °C at 760 mmHg
折射率:1.534
闪光点:232.2 °C
储存条件:2-8°C
PSA:134.91000
LOGP:4.69270
[1]. Yuan N, et al. Bafilomycin A1 targets both autophagy and apoptosis pathways in pediatric B-cell acute lymphoblastic leukemia. Haematologica. 2015 Mar;100(3):345-56.
[2]. Lu X, et al. Bafilomycin A1 inhibits the growth and metastatic potential of the BEL-7402 liver cancer and HO-8910 ovarian cancer cell lines and induces alterations in their microRNA expression. Exp Ther Med. 2015 Nov;10(5):1829-1834.
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