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HBX-41108

HBX-41108 924296-39-9
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产品信息
产品名称:HBX-41108 纯度:98% min
CAS NO:924296-39-9 溶解度:
分子式:C13H3ClN4O 包装:可按客户要求包装
分子量:266.642 贮存:-20℃
质量控制
备注说明

HBX 41108 is an inhibitor of ubiquitin-specific protease (USP) 7. HBX 41108 inhibits USP7 deubiquitinating activity with an IC(50) in the submicromolar range. HBX 41,108 was shown to affect USP7-mediated p53 deubiquitination in vitro and in cells. As RNA interference-mediated USP7 silencing in cancer cells, HBX 41,108 treatment stabilized p53, activated the transcription of a p53 target gene without inducing genotoxic stress, and inhibited cancer cell growth. HBX 41,108 induced p53-dependent apoptosis as shown in p53 wild-type and null isogenic cancer cell lines.


中文名称:

7-氯-9-氧代-9H-茚并[1,2-b]吡嗪-2,3-二甲腈


英文名称:

7-chloro-9-oxo-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile


物化属性:

密度:1.66

沸点:604.9°C at 760 mmHg

折射率:1.725

闪光点:319.6°C

PSA:90.43000

LOGP:2.08476

参考文献

1: Nicholson B, Suresh Kumar KG. The multifaceted roles of USP7: new therapeutic 
opportunities. Cell Biochem Biophys. 2011 Jun;60(1-2):61-8. doi: 
10.1007/s12013-011-9185-5. Review. PubMed PMID: 21468693.

2: Colland F, Formstecher E, Jacq X, Reverdy C, Planquette C, Conrath S, Trouplin 
V, Bianchi J, Aushev VN, Camonis J, Calabrese A, Borg-Capra C, Sippl W, Collura 
V, Boissy G, Rain JC, Guedat P, Delansorne R, Daviet L. Small-molecule inhibitor 
of USP7/HAUSP ubiquitin protease stabilizes and activates p53 in cells. Mol 
Cancer Ther. 2009 Aug;8(8):2286-95. doi: 10.1158/1535-7163.MCT-09-0097. Epub 2009 
Aug 11. PubMed PMID: 19671755.

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