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ML-211

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产品信息

产品名称：ML-211	纯度：98% min
CAS NO：ML-211	溶解度：Ethanol: ≤10mg/ml;DMSO: 30mg/ml
分子式：C₂₅H₃₀N₄O₂	包装：可按客户要求包装
分子量：418.53	贮存：-20℃

质量控制

备注说明

ML-211 was identified as a carbamate-based dual inhibitor of LYPLA1 and the related LYPLA2. ML-211 could inhibit the serine hydrolase ABHD11 (IC50: 10 nM) but was over 50-fold selective for LYPLA in a panel of 20 additional serine hydrolases. Given the high structural homology between LYPLA1 and LYPLA2, it was anticipated that ML211 modified LYPLA2 in an analogous manner. In addition, out of more than 20 serine hydrolases, ML211 was observed to have one anti-target, alpha/beta hydrolase domain-containing protein 11. ML211 and the anti-probe ML226 were evaluated for cell toxicity using both serum-free and serum-supplemented media, and the results showed that both compounds had a CC50 greater than 6 μM, which was 200-fold greater than the concentration necessary for complete inhibition of their respective target enzyme(s) .

参考文献

[1] Adibekian, A. ,Martin, B.R.,Speers, A.E., et al. Optimization and characterization of a triazole urea dual inhibitor for lysophospholipase 1 (LYPLA1) and lysophospholipase 2 (LYPLA2). 1 R01 CA132630, 1-42 (2013).